Description
Dosage
Composition
Literature
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A veterinary preparation that is a source of calcium, zinc, manganese and vitamin D3. Supports proper growth, skeletal mineralization and bone formation. Balances calcium deficiencies, has a positive effect on muscle function and the immune system.
The advanced formula of the preparation is based on the highest quality active ingredients, the effects of which have been scientifically confirmed:
Calcium is the basic building block of bones and teeth, it ensures proper mineralization of the skeleton and bone density during the growth period of the body [1,2,3]. It is an essential element for the production and activation of numerous enzymes and hormones that regulate digestion, fat and energy management of the body [4,5,6]. A proper supply of this element is necessary for maintaining proper blood clotting, because Ca affects the healing processes of wounds. Calcium cooperates with other macroelements during muscle contractions, including the heart muscle, supporting the maintenance of optimal muscle tension. Calcium is also essential for the proper functioning of the nervous system. Calcium deficiency or too low concentration in the blood causes nerve cells to become hypersensitive. Tetany (painful muscle contractions) may occur, which is particularly dangerous for pregnant and perinatal bitches. Calcium also supports the release of neurotransmitters in the nervous system [7,8].
Vitamin D plays an important role in the regulation of calcium-phosphorus metabolism and bone mineralization [1,7,8]. It increases the absorption of these elements from the digestive tract and also balances the incorrect calcium-phosphorus ratio [4,5]. Vitamin D facilitates the conversion of organic phosphorus into inorganic phosphorus, which is why it is essential in the processes of ossification and in the formation of compounds necessary for bone building. Vitamin D3 has a beneficial effect on the efficiency of the immune system. It has anti-inflammatory effects, has a positive effect on the production of antiallergic and anti-inflammatory cytokines, which is why it is also used in the treatment of allergies [1,9].
Zinc is one of the most important nutrients involved in bone metabolism and proper functioning of the skeletal system. Zinc is an essential mineral that is required for proper skeletal growth and bone homeostasis. Dietary zinc deficiency causes impaired development, inhibits skeletal growth and negatively affects bone quality. Numerous scientific publications indicate that zinc also seems to support bone regeneration after trauma and fractures/surgical interventions. Zinc supplementation may also be important in the case of osteoporosis [10,11].
Manganese is an essential trace element involved in many processes in the body, including bone formation. Manganese deficiency can impair bone formation and reduce bone mineral density, while manganese supplementation can increase both bone mineral density and support proper bone formation [12].
Available packages: 60 tablets.
Proper growth and mineralization of the skeleton
Dosage
Calcium+D3 V2
| ≥10 kg | 1 tablet | |
| 20 kg | 2 tablets | |
| 30 kg | 3 tablets |
Active substances
in 1 tablet
Calcium Chelate
500 mg
Zinc Chelate
5 mg
Manganese Chelate
1 mg
Vitamin D3
200 IU
Composition
Calcium Chelate (diglyciniate) 77%.
Additives (g/kg): Zinc Chelate (bisglicyniate) 7,7 g, Vitamin D3 (cholecalciferol) 3 g, Manganese Chelate (diglicynian) 1,54 g.
Technological additives (g/kg): microcrystalline cellulose 212 g, magnesium stearate 6 g.
Analytical constituents
- crude fat 0,5%
- crude protein 67%
- crude fibre 12%
- crude ash 39%
- calcium 17%
- Stockman J, Villaverde C, Corbee RJ. Calcium, Phosphorus, and Vitamin D in Dogs and Cats: Beyond the Bones. Vet Clin North Am Small Anim Pract. 2021 May;51(3):623-634. doi: 10.1016/j.cvsm.2021.01.003. Epub 2021 Feb 27. PMID: 33653533.
- Dobenecker B, Kasbeitzer N, Flinspach S, Köstlin R, Matis U, Kienzle E. Calcium-excess causes subclinical changes of bone growth in Beagles but not in Foxhounds, as measured in X-rays. J Anim Physiol Anim Nutr 2006; 90: 394-401.
- Vannucci L, Fossi C, Quattrini S, Guasti L, Pampaloni B, Gronchi G, Giusti F, Romagnoli C, Cianferotti L, Marcucci G, Brandi Calcium Intake in Bone Health: A Focus on Calcium-Rich Mineral Waters. Nutrients. 2018 Dec 5;10(12):1930.
- Hutchinson D, Freeman LM, McCarthy R, et al. Seizures and severe nutrient deficiencies in a puppy fed a homemade J Am Vet Med Assoc 2012;241: 477–83.
- Verbrugghe A, Paepe D, Verhaert L, et al. Metabolic bone disease and hyperparathyroidism in an adult dog fed an unbalanced homemade Vlaams Diergeneeskundig Tijdschrift 2011;80:61–8
- Lauten SD, Cox NR, Brawner Jr WR, Goodman SA, Hathcock JT, Montgomery RD, Kincaid SA, Morrison NE, Spano JS, Lepine AJ, Reinhart GA, Baker HJ. Influence of dietary calcium and phosphorus content in a fixed ratio on growth and development in Great Danes. Am J Vet Res 2002; 63: 1036-1047
- Ichikawa F., Katagiri, Higuchi Y., Takeda S., Saito K.: 1Alpha-hydroxyvitamin D3 prevents the decrease of bone mineral density in lactating beagles. J. Vet. Med. Sci. 2000, 62, 75-79.
- National Research Council (2006): Nutrient Requirements of Dogs and Cats, Washington, DC, The National Academies
- Weidner N, Verbrugghe A. Current knowledge of vitamin D in dogs. Crit Rev Food Sci Nutr 2017;57:3850–9. 8. Allison LN, Jaffey JA, Bradley-Siemens N, et al. Immune function and serum vitamin D in shelter dogs: a case-control study. Vet J 2020;261:105477.
- O’Connor JP, Kanjilal D, Teitelbaum M, Lin SS, Cottrell Zinc as a Therapeutic Agent in Bone Regeneration. Materials (Basel). 2020 May 12;13(10):2211.
- Ceylan MN, Akdas S, Yazihan Is Zinc an Important Trace Element on Bone-Related Diseases and Complications? A Meta-analysis and Systematic Review from Serum Level, Dietary Intake, and Supplementation Aspects. Biol Trace Elem Res. 2021 Feb;199(2):535-549.
- Rondanelli M, Faliva MA, Peroni G, et al. Essentiality of Manganese for Bone Health: An Overview and Update. Natural Product Communications. 2021;16(5).
Should Calcium be given to growing dogs?
If your dog is fed a complete food, there is no need for additional calcium supplementation unless deficiencies occur.
Will this product help erect drooping ears?
If the ear has drooped during the period of tooth replacement, it is worth giving Calcium to compensate for the calcium deficiency.
What is the dosage when feeding a home-cooked diet?
In home diets, we can use this product at a dose of 1 tablet per 100g of boneless food. However, for economic reasons, when balancing home diets, we recommend using the product Barfer Calcium.
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