Description
Dosage
Composition
Literature
FAQ
Reviews
The advanced formula of the preparation is based on the highest quality active ingredients, the effects of which have been scientifically confirmed:
Hydrolyzed collagen (<2500 Daltons) – nourishes and supports the regeneration of joints and other connective tissues in the body. It provides free amino acids, peptides and collagen fibers, necessary for the synthesis of collagen in the body [1]. Due to its low molecular weight, it has higher absorption and better bioactive properties [2]. Regularly supplemented, it improves the mobility and flexibility of joints, and visibly reduces pain in the course of degenerative joint and spine disease [3,4,5].
T2NDC® native type II collagen – through the mechanism of oral tolerance, initiates anti-inflammatory and cartilage protective pathways, thus reducing pain and inflammation in the joints [6,7,8]. Accelerates recovery after surgical treatment of cruciate ligament injury in dogs [9].
Hyaluronic acid – ensures proper viscosity and elasticity of the synovial fluid in the joint capsule, thus increasing joint flexibility and improving mobility [10,11,12].
Boswellia Serrata – It alleviates problems with the skeletal system by improving blood supply to the joints and is also responsible for reducing swelling, inhibiting inflammation and relieving pain in the joints [13,14].
MSM – supports the proper functioning of joints, has anti-inflammatory properties and relieves pain [15].
Glucosamine – takes an active part in the synthesis of glycosaminoglycans (GAG) [16]. It promotes cartilage regeneration and proper joint functioning. It increases the amount of synovial fluid in the joint capsule, which significantly reduces pain and facilitates movement [15,16,17,18].
Chondroitin – improves the elasticity of cartilage tissues and reduces painful joint swelling [17, 20]. Stimulates the biosynthesis of hyaluronic acid and proteoglycans, which give cartilage elasticity and resistance to deformation [21].
Vitamin C – stimulates the synthesis of proteoglycans, is necessary for the formation and secretion of ossein (a building block of bones). It enhances the processes of collagen synthesis and prevents its degeneration in the body [22].
Available packages: 150g, 250g, 500g, 550g refill pack (doypack)
The REFILL PACK 550 GRAM is a refill package and does not include a scoop.
Joint dysplasia
Degeneration of joints and spine
Inflammation in the joints
Dosage
AniFlexi+ V2
| 5 kg | 1 g | |
| 10 kg | 1,5 g | |
| 30 kg | 5 g |
The measuring scoop contains 1.5g of the product (AniFlexi+ 150g) or 5g of the product (AniFlexi+ 250g, AniFlexi+ 500g).
Active substances
in 1g of product
Hydrolyzed collagen
500 mg
T2NDC® native collagen type II
10 mg
Hyaluronic acid
10 mg
Siarczan glukozaminy
200 mg
Glucosamine sulfate
100 mg
Boswellia Serrata
100 mg
MSM
50 mg
Vitamin C
30 mg
Composition
Hydrolyzed collagen (beef) 50%, glucosamine sulfate (from marine crustaceans) 20%, chondroitin sulfate (beef) 10%, MSM 5%, sodium hyaluronate 1%, native collagen type II 1%.
Additives (g/kg)
Vitamin C 30 g
Sensory additives (g/kg)
Boswellia serrata extract (Boswellic acid – 65%) 100 g
Analytical constituents
- crude protein58%
- crude fat 0,5%
- crude fiber 0,5%
- crude ash 9%
1.Tang C., Zhou K., Zhu Y., Zhang W., Xie Y., Wang Z., Zhou H., Yang T., Zhang Q., Xu B. Collagen and Its Derivatives: From Structure and Properties to Their Applications in Food Industry. Food Hydrocoll. 2022, 131, 107748.
2. Hong H., Fan H., Chalamaiah M., Wu J. Preparation of Low-Molecular-Weight, Collagen Hydrolysates (Peptides): Current Progress, Challenges, and Future Perspectives. Food Chem. 2019, 301, 125222.
3. Weide N. Der Einsatz von Gelatinehydrolysat bei klinisch-orthopädisch gesunden Hunden und Hunden mit chronischen Erkrankungen des Bewegungsapparats. PhD thesis. Tierärztliche Hochschule Hannover, 2004.
4. Hesse, K.J.F. Supplementation by Collagen Hydrolysate in Dogs Suffering from Osteoarthritis. Kleintiermedizin.2006, 9, 17-22.
5. Bello AE, Oesser S. Collagen hydrolysate for the treatment of osteoarthritis and other joint disorders: a review of the literature. Curr Med Res Opin. 2006 Nov;22(11):2221-32.
6.Deparle L.A., Gupta R.C., Canerdy T.D., Goad J.T., D’Altilio M., Bagchi M., Bagchi D. Efficacy and Safety of Glycosylated Undenatured Type-II Collagen (UC-II) in Therapy of Arthritic Dogs. J. Vet. Pharmacol. Ther. 2005, 28, 385–390.
7. Zapata A., Fernández-Parra R. Management of Osteoarthritis and Joint Support Using Feed Supplements: A Scoping Review of Undenatured Type II Collagen and Boswellia serrata. Animals 2023, 13, 870.
8. D’Altilio M., Peal A., Alvey M., Simms C., Curtsinger A., Gupta R.C., Canerdy T.D., Goad, J.T., Bagchi M., Bagchi D. Therapeutic efficacy and safety of undenatured type II collagen singly or in combination with glucosamine and chondroitin in arthritic dogs. Toxicol. Mech. Methods 2007, 17, 189–196.
9. Assies M., Berger B., Stegen B., Bottcher P. Non-denatured type 2 collagen – Efects on convalescence and osteoarthrits progression afer TPLO in dogs. A prospectve, blinded and randomised study. Virtual Esvot Congress, 2021.
10. Evanko S.P., Tammi M.I., Tammi R.H., Wight T.N. Hyaluronan-dependent pericellular matrix. Adv. Drug Deliv. Rev. 2007, 59, 1351–1365.
11. Plickert H., Bondzio A., Einspanier R., Tichy A., Brunnberg, L. Hyaluronic acid concentrations in synovial fluid of dogs with different stages of osteoarthritis. Res. Veter. Sci. 2013, 94, 728–734.
12. Serra Aguado C.I., Ramos-Plá J.J., Soler C., Segarra S., Moratalla V., Redondo J.I. Effects of Oral Hyaluronic Acid Administration in Dogs Following Tibial Tuberosity Advancement Surgery for Cranial Cruciate Ligament Injury. Animals (Basel). 2021 Apr 27;11(5):1264.
13. Reichling J., Schmökel H., Fitzi J., Bucher S., Saller R. Dietary support with Boswellia resin in canine inflammatory joint and spinal disease. Schweiz Arch Tierheilkd. 2004 Feb;146(2):71-9.
14. Martello E., Bigliati M., Adami R., Biasibetti E., Bisanzio D., Meineri G., Bruni N. Efficacy of a dietary supplement in dogs with osteoarthritis: A randomized placebo-controlled, double-blind clinical trial. PLoS One. 2022 Feb 16;17(2):e0263971.
15. Pagonis, Thomas & Givissis, Panagiotis & Kritis, Aristeidis & Christodoulou, Anastasios. The Effect of Methylsulfonylmethane on Osteoarthritic Large Joints and Mobility. International Journal of Orthopaedics, 2014. 1. 1-6.
16. Henrotin Y., Mobasheri A., Marty M. Is there any scientific evidence for the use of glucosamine in the management of human osteoarthritis? Arthritis Res Ther. 2012;14(1):201.
17. Jerosch J. Effects of glucosamine and chondroitin sulfate on cartilage metabolism in OA: outlook on other nutrient partners especially omega-3 fatty acids. Int. J. Rheumatol. 2011;2011:969012.
18. Dodge G.R., Regatte R.R., Noyszewski E.A., Hall J.O., Sharma A.V., Callaway D.A., Reddy R. The Fate of Oral Glucosamine Traced by (13)C Labeling in the Dog. Cartilage. 2011 Jul;2(3):279-85.
19. Wenz W., Hornung C., Cramer C., Schroeder M., Hoffmann M. Effect of Glucosamine Sulfate on Osteoarthritis in the Cruciate-Deficient Canine Model of Osteoarthritis. Cartilage. 2017 Apr;8(2):173-179.
20. McCarthy G., O’Donovan J., Jones B., McAllister H., Seed M., Mooney C. Randomised double-blind, positive-controlled trial to assess the efficacy of glucosamine/chondroitin sulfate for the treatment of dogs with osteoarthritis. Vet J. 2007;174(1):54-61.
21. Iovu M., Dumais G., du Souich P. Anti-inflammatory activity of chondroitin sulfate. Osteoarthritis Cartilage 2008;16(suppl 3):S14–S18
22. Ripani U, Manzarbeitia-Arroba P, Guijarro-Leo S, Urrutia-Graña J, De Masi-De Luca A. Vitamin C May Help to Reduce the Knee’s Arthritic Symptoms. Outcomes Assessment of Nutriceutical Therapy. Med Arch. 2019 Jun;73(3):173-177.
What is the difference between AniFlexi + and AniFlexi HA?
Both products are dedicated to dogs with diagnosed problems in the musculoskeletal system. AniFlexi HA is a tablet product, and AniFlexi+ is a powder product. AniFlexi+ contains two additional substances: Boswellia Serrata and native collagen type II, which makes AniFlexi+ an excellent choice for dogs with highly advanced musculoskeletal disease.
Is this product suitable for puppies?
The product is safe for puppies and is an excellent choice for disorders of the motor system development in growing dogs. However, if the puppy is healthy and does not show any problems with the motor system, then we definitely recommend AniFlexi Fit – a product dedicated to supporting the development of the motor system of puppies.
Can this product be dissolved in water?
Absolutely, AniFlexi+ is a product that dissolves well in water, but you should use lukewarm or cold water. You can also mix it with egg or animal fat for flavor.
Should I take breaks from use?
We do not recommend taking breaks in using this product.
5 reviews for Game Dog AniFlexi+V2
Only logged in customers who have purchased this product may leave a review.
Izabela –
Świetny suplement na stawy dla starszego psa, ze zwyrodnieniami. Bardzo ekonomiczne opakowanie, niestety dość drogie w zakupie, ale wystarcza na wiele miesięcy. Pies chętnie je wymieszane z karmą. Widze wyraźną poprawę w poruszaniu się psa.
Piotr –
Bardzo skuteczny ale drogi, dlatego 4 gwiazdki. Mam dwa psy jeden je bardzo chętnie, drugiemu muszę mieszać z mokra karmą. Pies ze zwyrodnieniami przestał kuleć i zaczął chętniej się poruszać po około miesiącu używania.
Piotr –
Najlepszy dodatek na stawy jaki używaliśmy. Pies chętnie zjada, a efekty widać już po kilku tygodniach stosowania – dużo łatwiej i chętniej wstaje, zmniejszyła się kulawizna w tylnej łapie. Pies w ogóle chętniej i bardziej energicznie się porusza. Opakowanie bardzo wydajne, dla owczarka staroniemieckiego (ponad 40kg) wystarcza na ponad 2 miesiące. Polecam!!
Marta –
Zdecydowanie najlepszy suplement przy zwyrodnieniach stawów, który testowaliśmy. Moj pies dostaje go od ponad roku, jest zdecydowanie bardziej ruchliwy. I bardzo psu smakuje.
Sandra i Bruno –
Świetny suplement. Dla mojego border collie, który lada dzień będzie kończył rok to jest świetne. Zaczęłam stosować proszek odkąd miał parę miesięcy i miał parę tygodni problem z tylną łapa bo ciągle utykał a vet nic nie widział… Dosłownie po 3tyg użytkownika codziennego tego proszku pies jak nowo narodzony, pędzi aż tylko się kurzy 🙂 także polecam dla szczeniaków i dorastających psów również.