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Veterinary preparation for dogs, supporting the proper functioning of the digestive system and the reconstruction of intestinal microflora in animals. Dedicated as dietary support for dogs with digestive system microflora disorders, including after antibiotic therapy, in digestive disorders, in the case of a tendency to diarrhea or constipation, after deworming procedures and during periods of exposure to stress (travel, exhibitions, sports competitions). Three clinically tested strains of probiotic bacteria support the growth of beneficial intestinal microflora, while limiting potentially pathogenic bacteria.
The advanced formula of the preparation is based on three probiotic strains whose effects have been confirmed by scientific research:
Lactobacillus acidophilus – by producing lactic acid and lowering pH in the small intestine, it inhibits the growth of harmful pathogens and blocks the adhesion of Clostridium perfringens bacteria to the intestinal mucosa. It actively participates in the synthesis of B vitamins, especially niacin, folic acid and vitamin B6 [1,2,3,4]. The specificity of L. acidophilus is its ability to hydrolyze urea, which allows, on the one hand, to reduce its endogenous production, and also supports the reduction of its concentration in the blood during chronic renal failure [5,6].
Oralin® – contains live lactic acid bacteria Enterococcus faecium, which have probiotic effects and are capable of rapidly multiplying in the small intestine. They produce lactic acid, lower the pH in the small intestine, inhibit the growth of pathogenic bacteria, create the so-called intestinal barrier – they prevent the adhesion of pathogens to the intestinal mucosa. They produce antibacterial compounds and compete with pathogens for nutrients [7,8,9,10].
Calsporin® – contains the spore-forming bacteria Bacillus velezensis (formerly Bacillus subtilis). They have a protective coating, thanks to which they are able to safely reach the large intestine. The presence of a protective coating makes them resistant to destruction by antibiotics, so they can be administered during antibiotic therapy. B. velezensis bacteria have a multifaceted effect on the proper functioning of the intestines. Bacillus strains support the immune system of animals by stimulating the production of immunoglobulin IgA and improving the structure of the intestinal mucosa (preventing intestinal leakage). Bacillus strains effectively inhibit diarrhea. Some scientific studies show that Bacillus strains may also have anti-cancer effects [11,12,13,14].
Inulin – a natural prebiotic, stimulates the growth of beneficial intestinal microflora
Available packages: 60 capsules
Intestinal microbiota disorders
Dosage
Flora Protect
| ≤20 | 1 capsule | |
| ≥20 | 1-2 capsules |
Active substances
in 1 capsule
Lactobacillus acidophilus D2/CLS CECT 4529
Oralin® (Enterococcus faecium DSM 10663 NCIMB 10415)
Calsporin® (Bacillus velezensis DSM 15544)
Inulin
Composition:
inulin 50%, rice starch 50%.
Zootechnical additives:
Oralin® Enterococcus faecium DSM 10663 NCIMB 10415 1,48×10 12 cfu/kg,
Calsporin® Bacillus velezensis DSM 15544 (dawniej Bacillus
subtilis C-3102) 1,48×10 12 cfu/kg,
Lactobacillus acidophilus D2/CLS CECT 4529 3,11×10 12 cfu/kg
Skład analityczny
- crude protein 3%
- crude fibre 0.2%
- crude oils and facts 0.6%
- crude ash 12%
- Kelly S. Swanson, Christine M. Grieshop, Elizabeth A. Flickinger, Laura L. Bauer, JoMay Chow, Bryan W. Wolf, Keith A. Garleb, George C. Fahey, Fructooligosaccharides and Lactobacillus acidophilus Modify Gut Microbial Populations, Total Tract Nutrient Digestibilities and Fecal Protein Catabolite Concentrations in Healthy Adult Dogs, The Journal of Nutrition, Volume 132, Issue 12, 2002, Pages 3721-3731.
- Baillon ML, Marshall-Jones ZV, Butterwick RF. Effects of probiotic Lactobacillus acidophilus strain DSM13241 in healthy adult dogs. Am J Vet Res. 2004.
- Marelli SP, Fusi E, Giardini A, Martino PA, Polli M, Bruni N, Rizzi R. Effects of probiotic Lactobacillus acidophilus D2/CSL (CECT 4529) on the nutritional and health status of boxer dogs. Vet Rec. 2020.
- Bruni, N.; Martello, E.; Fusi, E.; Meineri, G.; Giardini, A. Study of faecal parameters and body condition in dogs with a diet supplemented with Lactobacillus acidophilus D2/CSL (CECT 4529). Ital. J. Anim. Sci. 2020, 19, 704–711.
- Lippi, I.; Perondi, F.; Ceccherini, G.; Marchetti, V.; Guidi, G. Effects of probiotic VSL#3 on glomerular filtration rate in dogs affected by chronic kidney disease: A pilot study. Can. Vet. J. 2017, 58, 1301–1305.
- Fagundes RAB, Soder TF, Grokoski KC, Benetti F, Mendes RH. Probiotics in the treatment of chronic kidney disease: a systematic review. J Bras Nefrol. 2018 Jul-Sep;40(3):278-286.
- 7. Rose, L.; Rose, J.; Gosling, S.; Holmes, M. Efficacy of a Probiotic-Prebiotic Supplement on Incidence of Diarrhea in a Dog Shelter: A Randomized, Double-Blind, Placebo-Controlled J. Vet. Intern. Med. 2017, 31, 377–382
- Scientific Opinion on the safety and efficacy of Oralin®(Enterococcus faecium) as a feed additive for calves for rearing, piglets, chickens for fattening, turkeys for fattening and dogs. EFSA Journal, 12(6), 2014, 3727
- Bybee SN, Scorza AV and Lappin MR (2011). Effect of the probiotic Enterococcus faecium SF68 on presence of diarrhoea in cats and dogs housed in an animal shelter, J Vet Internal Med 25(4): 856-860
- Benyacoub J, Czarnecki-Maulden GL, Cavadini C et al (2003). Supplementation of food with Enterococcus faecium (SF68) stimulates immune functions in young dogs, J Nutr 133(4): 1,158-1,162
- Schauf S., Nakamura N., Castrillo Effect of Calsporin® (Bacillus subtilis C-3102) addition to the diet on faecal quality and nutrient digestibility in healthy adult dogs. Journal of Applied Animal Nutrition. 2019.
- Daniele Cristina de Lima, Camilla Mariane Menezes Souza, Noriko Nakamura, Dany Mesa, Simone Gisele de Oliveira, Ananda Portella Félix, Dietary supplementation with Bacillus subtilis C-3102 improves gut health indicators and fecal microbiota of dogs, Animal Feed Science and Technology, Volume 270, 2020.
- 13. Paap P.M., Van der LaakH., Smit J.I., Nakamura N. and Beynen A.C. 2016. Administration of Bacillus subtilis C-3102 (Calsporin®) may improve feces consistency in dogs with chronic diarrhea. Res. Opin. Anim. Vet. Sci., 6(8): 256-260.
- 14. Lima, D.C. de, et al. Dietary supplementation with Bacillus subtilis C-3102 improves gut health indicators and fecal microbiota of dogs. Animal Feed Science and Technology. 270, 2020, 114672, p.
What does it mean that this product is a synbiotic?
This means that this product contains both probiotic and prebiotic bacteria.
What is the difference between a probiotic and a prebiotic?
A prebiotic is food for probiotic bacteria.
Is this product used continuously?
In the case of generally healthy dogs, probiotics are usually introduced for a short period of time (10-20 days) in the event of severe stress, diarrhea, etc. Dogs suffering from digestive or immune system problems should be given probiotics long-term (over 30 days) or continuously, depending on the recommendations of the veterinarian treating the dog.
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